You followed the protocol. You took the medication. You dealt with the side effects and stayed consistent. And the scale barely moved. Or you felt sick enough that you had to stop before the medication had a real chance to work. If that is your experience, there is something important you may not have been told before you started. Genetic variation plays a significant role in how well GLP-1 medications work and how severely patients experience side effects. For some patients,

White Olive Direct Personalized Care | Dr. Jeffrey Shukhman | whiteolivedpc.com When I sit down with a new patient and we talk about weight, I am not thinking about calories first. And when someone asks me why does weight come back after Ozempic, my answer is almost always the same. It is not willpower. It is not the medication failing. It is four metabolic patterns that were already working against them before the prescription was written — and that are still there after it

Dr. Shukhman reviewing labs with a patient If you live in Calabasas or the surrounding communities and you're paying any attention to what's happening in medicine right now, you've heard about GLP-1 medications. Ozempic, Wegovy, Mounjaro, Zepbound. You've probably seen the weight-loss headlines and the before-and-after photos. What you may not have heard, and what I want to talk about in this post, is that the medical community is starting to look at GLP-1s in a very differen

The idea of a weight-loss pill naturally gets attention. For many people, a daily tablet sounds simpler, easier, and less intimidating than a weekly injection. And now that Wegovy tablets are part of the current U.S. prescribing information, it is reasonable for patients to ask an important question: Are Wegovy pills as effective as the shots? The honest answer is: They appear to be effective, but injectable Wegovy still looks somewhat stronger on average based on the current